November 1, 1990Acta Physiologica Scandinavica
Role of endothelium‐derived nitric oxide in the regulation of tonus in large‐bore arterial resistance vessels, arterioles and veins in cat skeletal muscle
Population
Cat skeletal muscle (whole-organ technique)
Comparison
NG-monomethyl-L-arginine 3-100 mg kg-1 tissue… vs Control
Design
Preclinical
Follow-up
up to 1 hour
Authors
Discussion
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Member takes
Implication
Highlights large-artery NO dominance in this animal model; leaves open human translation.
Structured PICO
P
Population
Cat skeletal muscle (whole-organ technique)
I
Intervention
NG-monomethyl-L-arginine (L-NMMA) 3-100 mg kg-1 tissue, intra-arterial
C
Comparator
Control (baseline or excess L-arginine 300 mg kg-1)
O
Outcome
Vascular resistance in the whole vascular bed (RT) and its three consecutive sections (large-bore arterial resistance vessels, small arterioles, and veins)surrogate
Nitric oxide formation by the vascular endothelium is crucial for regulating in vivo vascular tone, primarily in large-bore arterial resistance vessels.
Cite This Study
Ekelund et al. (1990) studied this question.