Why the study?
Does endogenous nitric oxide modulate microvascular tone and mediate vasomotor nerve-induced vasodilation in vivo?
Population
Rabbit tenuissimus muscle model (in vivo)
Comparison
N omega-nitro-L-arginine methylester or… vs Baseline conditions, reversal with L-arginine vs…
Design
Preclinical
Authors
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Animal data implicate endogenous NO in microvascular tone; leaves open human translation and clinical relevance.
Does endogenous nitric oxide modulate microvascular tone and mediate vasomotor nerve-induced vasodilation in vivo?
Endogenous nitric oxide is a key modulator of resting microvascular tone and is required for vasomotor nerve-induced vasodilation, but not for myogenic vasodilation or functional hyperemia.
Persson et al. (1991) studied this question.
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