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March 1, 1993British Journal of PharmacologyOpen Access

The effect of NG‐nitro‐l‐arginine methyl ester upon basal blood flow and endothelium‐dependent vasodilatation in the dog hindlimb

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Population

Dog skinned hindlimb model (n=4)

Comparison

NG-nitro-L-arginine methyl ester 0.1-3 mg min-1… vs Baseline and pretreatment/co-infusion with…

Design

Preclinical

Authors

DWDavid G. WhiteGDG.M. DrewJGJ GURDEN

Discussion

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Overview

In a dog hindlimb model, NO synthase inhibition with L-NAME reduces basal blood flow and attenuates endothelium-dependent vasodilation, confirming the role of NO in skeletal muscle vascular regulation.

Structured PICO

P
Population
Dog skinned hindlimb model (n=4)
I
Intervention
NG-nitro-L-arginine methyl ester (L-NAME) 0.1-3 mg min-1 infused directly into the iliac artery
C
Comparator
Baseline and pretreatment/co-infusion with L-arginine (100 mg min-1)
O
Outcome
Basal iliac artery blood flow and vasodilator responses to endothelium-dependent and -independent agonistssurrogate

In a dog hindlimb model, NO synthase inhibition with L-NAME reduces basal blood flow and attenuates endothelium-dependent vasodilation, confirming the role of NO in skeletal muscle vascular regulation.

Cite This Study

White et al. (1993) studied this question.

synapsesocial.com/papers/6a708196af0c21e939284e45https://doi.org/10.1111/j.1476-5381.1993.tb12875.x
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