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December 1, 1991Fundamental and Clinical Pharmacology

The l ‐arginine — nitric oxide pathway in the canine femoral vascular bed: in vitro and in vivo experiments

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Population

Canine femoral vascular bed

Design

Preclinical

Authors

VRVincent RichardMGM. GosgnachCRChristophe Drieu La Rochelle

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Overview

The study demonstrates that basal nitric oxide release maintains vasodilator tone in canine femoral arteries, and its inhibition by L-NAME causes supersensitivity to nitrovasodilators.

Structured PICO

P
Population
Canine femoral vascular bed (in vitro isolated canine femoral arteries and in vivo conscious dogs chronically instrumented for measurement of iliac blood flow and artery diameter)
I
Intervention
L-NAME (NG-nitro L-arginine methyl ester)
O
Outcome
Femoral arterial tone (in vitro isometric tension, in vivo iliac blood flow and iliac artery diameter)surrogate

The study demonstrates that basal nitric oxide release maintains vasodilator tone in canine femoral arteries, and its inhibition by L-NAME causes supersensitivity to nitrovasodilators.

Cite This Study

Richard et al. (1991) studied this question.

synapsesocial.com/papers/6a91243300275324e082fb0bhttps://doi.org/10.1111/j.1472-8206.1991.tb00767.x
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