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April 1, 1995British Journal of PharmacologyOpen Access

Comparison of effects of chronic and acute administration of NG‐nitro‐L‐arginine methyl ester to the rat on inhibition of nitric oxide‐mediated responses

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Population

Rats

Comparison

NG-nitro-L-arginine methyl ester administered… vs Age-matched control animals

Design

Preclinical

Authors

CBClare BryantGAGraham H. AllcockTWTimothy D. Warner

Discussion

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Overview

Suggests tissue-specific compensatory vasodilator pathways; leaves open differential NO dependence across vascular beds in hypertension models.

Structured PICO

P
Population
Rats (in vivo and in vitro preparations including isolated perfused kidney, thoracic aorta rings, trachea, and anococcygeus muscles)
I
Intervention
NG-nitro-L-arginine methyl ester (L-NAME) administered chronically (approx 70 mg kg-1) or acutely (3-100 mumol kg-1)
C
Comparator
Age-matched control animals
O
Outcome
Vascular responses to acetylcholine and sodium nitroprusside in vivo and in vitrosurrogate

Chronic L-NAME administration inhibits endothelial nitric oxide production but does not uniformly alter acetylcholine vasodepressor activity across different tissues, suggesting differential regulation or alternative vasodilator pathways.

Cite This Study

Bryant et al. (1995) studied this question.

synapsesocial.com/papers/6a86ae2b6fbb37794f7cab19https://doi.org/10.1111/j.1476-5381.1995.tb14956.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of chronic treatment with nitric oxide synthase inhibitors on regional haemodynamic responses to vasodilators in conscious Brattleboro rats1993 · 17 citations
  2. 2Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase.1992 · 260 citations
  3. 3Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.1992 · 794 citations
  4. 4Persistent hypertension following inhibition of nitric oxide formation in the young Wistar rat: role of renin and vascular hypertrophy1993 · 91 citations
  5. 5Chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.1992 · 735 citations