June 30, 2010Fundamental and Clinical Pharmacology

Acute intravenous injection and short‐term oral administration of NG‐nitro‐l‐arginine methyl ester to the rat provoke increased pressor responses to agonists and hypertension, but not inhibition of acetylcholine‐induced hypotensive responses

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Population

Pithed and anesthetized rats

Design

Preclinical

Follow-up

Up to 3 days

Authors

RLRuth M. LópezClínica Alemana MPMaria T. PerezConsejo Superior de Investigaciones Científicas CCCarlos CastilloInstitució Catalana de Recerca i Estudis Avançats

Discussion

Member takes

Implication

NO synthase inhibition augments pressor reactivity without altering acetylcholine responses in rats; hypothesis-generating and leaves open human relevance.

Structured PICO

Population

Pithed and anesthetized rats

Intervention

Acute intravenous injection (100 mg/kg) and short-term oral administration of N(G)-nitro-L-arginine methyl ester (L-NAME; 60 mg/kg per day) for 1 and 3 days

Outcome

Vascular responses to acetylcholine, phenylephrine, and angiotensin II, and mean arterial pressure (MAP)surrogate

Inhibition of NO synthesis by L-NAME in rats increases vascular smooth muscle hyper-responsiveness to pressor agonists and causes hypertension, without altering acetylcholine-induced hypotensive responses in vivo.

Cite This Study

López et al. (2010) studied this question.

synapsesocial.com/papers/6a86ae2b6fbb37794f7cab07 https://doi.org/10.1111/j.1472-8206.2010.00852.x

Topics

Hypertension management

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Implication

NO synthase inhibition augments pressor reactivity without altering acetylcholine responses in rats; hypothesis-generating and leaves open human relevance.

Acute intravenous injection and short‐term oral administration of NG‐nitro‐l‐arginine methyl ester to the rat provoke increased pressor responses to agonists and hypertension, but not inhibition of acetylcholine‐induced hypotensive responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Acute intravenous injection and short‐term oral administration of NG‐nitro‐l‐arginine methyl ester to the rat provoke increased pressor responses to agonists and hypertension, but not inhibition of acetylcholine‐induced hypotensive responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider