What is the clinical evidence from this study?

Study design: Other. Intervention: NG-monomethyl-l-arginine (l-NMMA) and NG-nitro-l-arginine methyl ester (l-NAME). Primary outcome: Hemodynamic responses (blood pressure, heart rate, regional blood flows).

What does this research mean for the field?

Inhibition of nitric oxide synthase with l-NMMA or l-NAME produces dose-dependent hypertension and marked regional vasoconstriction in conscious rats, demonstrating substantial basal nitric oxide-mediated vasodilator tone in vivo. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1991Journal of Cardiovascular Pharmacology

Hemodynamic Effects of NG-Monomethyl-l-Arginine and NG-Nitro-l-Arginine Methyl Ester in Conscious, Unrestrained Rats

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Key result

Intravenous l-NMMA and l-NAME drive dose-dependent hypertension and vasoconstriction in rats via NO-mediated tone.

Population

Male, Long Evans and homozygous Brattleboro rats chronically instrumented with pulsed Doppler probes or…

Design

Preclinical

Authors

SGSheila M. GardinerUniversity of Nottingham ACA.M. ComptonAlbert Einstein College of Medicine PKPhilip A. KempUniversity of Nottingham

Discussion

Member takes

Implication

Establishes NO-mediated vasodilator tone in conscious rats; leaves open translation to human endothelial therapies.

Structured PICO

Population

Male Long Evans and homozygous Brattleboro rats chronically instrumented to monitor regional blood flows and cardiac output.

Intervention

Intravenous bolus doses of NG-monomethyl-l-arginine (l-NMMA, 0.3-300 mg/kg) and NG-nitro-l-arginine methyl ester (l-NAME, 0.1-10 mg/kg), or drinking water containing l-NMMA (1 mg/ml) or l-NAME (0.1 mg/ml)

Outcome

Hemodynamic responses including mean arterial blood pressure, heart rate, regional blood flows, and cardiac outputsurrogate

In conscious rats, inhibition of NO synthesis with l-NMMA or l-NAME causes dose-dependent hypertension and regional vasoconstriction, highlighting substantial NO-mediated vasodilator tone in vivo.

Limitations

Inhibition of NO-mediated tone does not give a quantitative estimate of its importance because the pressor effect is opposed by a marked reduction in cardiac function.

Cite This Study

Gardiner et al. (1991) studied this question. NG-monomethyl-l-arginine (l-NMMA) and NG-nitro-l-arginine methyl ester (l-NAME) was evaluated on Hemodynamic responses (blood pressure, heart rate, regional blood flows). Intravenous l-NMMA and l-NAME produced dose-dependent hypertension and marked regional vasoconstriction in conscious rats, consistent with substantial NO-mediated vasodilator tone.

synapsesocial.com/papers/6aa772a9ca6d36c98445680b https://doi.org/10.1097/00005344-199117003-00033

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Hemodynamic Effects of NG-Monomethyl-l-Arginine and NG-Nitro-l-Arginine Methyl Ester in Conscious, Unrestrained Rats

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Hemodynamic Effects of NG-Monomethyl-l-Arginine and NG-Nitro-l-Arginine Methyl Ester in Conscious, Unrestrained Rats

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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