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April 1, 1995American Journal of Hypertension

Overall Hemodynamic Studies After the Chronic Inhibition of Endothelial-Derived Nitric Oxide in Rats

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Why the study?

Does chronic administration of L-NAME alter systemic and regional hemodynamics in male Sprague Dawley rats?

Population

16 male Sprague Dawley rats

Comparison

Oral nitro-L-arginine methyl ester solution at a… vs Tap water for 4 weeks

Design

Preclinical

Follow-up

4 weeks

Authors

MHMin Huang

Discussion

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Overview

L-NAME models nitric oxide-deficient hypertension with low output in rats; extends experimental paradigms but leaves open human translation.

Structured PICO

Does chronic administration of L-NAME alter systemic and regional hemodynamics in male Sprague Dawley rats?

P
Population
16 male Sprague Dawley rats
I
Intervention
Oral nitro-L-arginine methyl ester (L-NAME) solution at a dose of 0.1 mg/mL in the drinking water ad libitum for 4 weeks
C
Comparator
Tap water for 4 weeks
O
Outcome
Mean arterial blood pressure, cardiac output, and individual organ flows measured 4 weeks after treatmentsurrogate

Chronic inhibition of endothelium-derived nitric oxide in rats leads to sustained hypertension, reduced cardiac output, and widespread regional vasoconstriction.

Cite This Study

Min Huang (1995) studied this question.

synapsesocial.com/papers/6a82b47c5bcab2ccdb8d67b9https://doi.org/10.1016/0895-7061(94)00203-n
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of effects of chronic and acute administration of N<sup>G</sup>‐nitro‐L‐arginine methyl ester to the rat on inhibition of nitric oxide‐mediated responses1995 · 46 citations
  2. 2Long-Term Vascular Effects of Nω-Nitro-L-Arginine Methyl Ester are Not Solely Mediated by Inhibition of Endothelial Nitric Oxide Synthesis in the Rat Mesenteric Artery1999 · 18 citations
  3. 3Systemic and regional hemodynamics after nitric oxide synthase inhibition: role of a neurogenic mechanism1994 · 22 citations
  4. 4Chronic-low-dose L-NAME treatment increases nitric oxide production and vasorelaxation in normotensive rats2007 · 23 citations
  5. 5Renal Dysfunction After Chronic Blockade of Nitric Oxide Synthesis2002 · 9 citations