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January 1, 1998HypertensionOpen Access

Evolution of Chronic Nitric Oxide Inhibition Hypertension

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Why the study?

Does chronic nitric oxide inhibition with L-NAME increase blood pressure and alter renal function in conscious rats?

Population

Conscious, chronically catheterized rats not subjected to acute experimental stress

Comparison

Acute N-nitro-L-arginine methylester 37… vs Baseline measurements before L-NAME administration

Design

Preclinical

Follow-up

21 days

Authors

CQChangbin QiuDMDianne G. MuchantWBWilliam H. Beierwaltes

Discussion

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Overview

Does not inform clinical hypertension management; leaves open translation of nitric oxide inhibition models to human disease.

Structured PICO

Does chronic nitric oxide inhibition with L-NAME increase blood pressure and alter renal function in conscious rats?

P
Population
Conscious, chronically catheterized rats not subjected to acute experimental stress
I
Intervention
Acute N-nitro-L-arginine methylester (L-NAME) 37 micromol/kg IV followed by chronic oral L-NAME approximately 37 micromol/kg per 24 hours for 21 days
C
Comparator
Baseline measurements before L-NAME administration
O
Outcome
Blood pressure and renal function (including renal vascular resistance, proteinuria, and glomerular filtration rate)surrogate

Chronic nitric oxide inhibition in rats causes severe hypertension and renal damage independent of sustained plasma renin activity stimulation.

Cite This Study

Qiu et al. (1998) studied this question.

synapsesocial.com/papers/6a842f2be22b852b8ec52a20https://doi.org/10.1161/01.hyp.31.1.21
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