Key result
L-NNA and L-NAME increased perfusion pressure and reduced vasodilator responses to acetylcholine in the hindquarters vascular bed of cats, with different dose and time exposures required.
Why the study?
Do nitric oxide synthesis inhibitors (L-NNA and L-NAME) alter vascular resistance and responses to acetylcholine in cats?
Do nitric oxide synthesis inhibitors (L-NNA and L-NAME) alter vascular resistance and responses to acetylcholine in cats?
Nitric oxide synthesis inhibitors increase vascular resistance and reduce acetylcholine-induced vasodilation in cats, with differing dose and time dependencies for these two effects.
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Warrants caution against clinical extrapolation; extends preclinical vascular models but leaves open human translation.
Bellan et al. (1993) studied this question. N omega-nitro-L-arginine (L-NNA) and N omega-nitro-L-arginine methyl ester (L-NAME) was evaluated on Vascular resistance and vasodilator response to acetylcholine. L-NNA and L-NAME increased perfusion pressure and reduced vasodilator responses to acetylcholine in the hindquarters vascular bed of cats, with different dose and time exposures required.
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