Why the study?
Does L-NAME selectively inhibit pulmonary vasodilator responses to acetylcholine and bradykinin in the intact-chest cat?
Population
Intact-chest cat model
Comparison
Intravenous administration of N… vs Control period (before L-NAME administration)
Design
Preclinical
Authors
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L-NAME effects in cats should not guide therapy; leaves open nitric oxide's role in human pulmonary vascular regulation.
Does L-NAME selectively inhibit pulmonary vasodilator responses to acetylcholine and bradykinin in the intact-chest cat?
L-NAME selectively inhibits endothelium-dependent pulmonary vasodilation in cats, supporting the role of EDRF/nitric oxide in regulating pulmonary vascular tone.
McMahon et al. (1991) studied this question.
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