Why the study?
Does L-NAME block the pulmonary vasodilator response to efferent vagal stimulation in the intact-chest cat?
Population
Intact-chest cat model with controlled blood flow and constant left atrial pressure, with pulmonary vascular…
Comparison
N omega-nitro-L-arginine methyl ester 100 mg/kg… vs Baseline responses prior to L-NAME administration
Design
Preclinical
Authors
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Supports NO mediation of vagal pulmonary vasodilation in cats; leaves open translation to human pulmonary vascular disease.
Does L-NAME block the pulmonary vasodilator response to efferent vagal stimulation in the intact-chest cat?
Efferent vagal stimulation dilates the pulmonary vascular bed via a cholinergic mechanism that stimulates the production of nitric oxide from L-arginine.
McMahon et al. (1992) studied this question.
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