Population
Intact pulmonary vascular bed of the cat and isolated pulmonary arterial rings
Comparison
Atrial natriuretic peptide administered with and… vs Control conditions
Design
Preclinical
Authors
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NO modulation of ANP responses may be resistance-vessel specific in felines; leaves open translational relevance to human pulmonary vascular disease.
In the feline pulmonary vascular bed, ANP induces endothelium-independent vasodilation via ANP-A/B receptors, which is modulated by nitric oxide specifically in resistance vessels.
Hyman et al. (2001) studied this question.
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