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March 1, 1992Cardiovascular Research23 citations

Nitric oxide does not mediate flow induced endothelium dependent arterial dilatation in the cat

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Why the study?

Does inhibition of nitric oxide synthesis prevent flow-induced endothelium-dependent arterial dilatation in cats?

Population

14 anaesthetised cats of either sex, weight 2.6-3.9 kg

Comparison

Intravenous administration of… vs Baseline state before inhibition of endothelium…

Design

Preclinical

Authors

AMArthur M. MelkumyantsSBSergey A. BalashovAKA. N Klimachev

Discussion

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Overview

Flow-induced endothelium-dependent arterial dilatation in the feline femoral artery is not mediated by nitric oxide derived from L-arginine.

Structured PICO

Does inhibition of nitric oxide synthesis prevent flow-induced endothelium-dependent arterial dilatation in cats?

P
Population
14 anaesthetised cats of either sex, weight 2.6-3.9 kg
I
Intervention
Intravenous administration of NG-nitro-L-arginine methyl ester and NG-monomethyl-L-arginine in doses 10 and 30 mg.kg-1
C
Comparator
Baseline state before inhibition of endothelium derived nitric oxide synthesis
O
Outcome
Changes in diameter of feline femoral artery caused by blood flow rate increases, acetylcholine, and ATPsurrogate

Flow-induced endothelium-dependent arterial dilatation in the feline femoral artery is not mediated by nitric oxide derived from L-arginine.

Cite This Study

Melkumyants et al. (1992) studied this question.

synapsesocial.com/papers/6a83fac4d65172829ee670bfhttps://doi.org/10.1093/cvr/26.3.256
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo1995 · 1,621 citations
  2. 2The effect of NG‐nitro‐L‐arginine methyl ester upon hindlimb blood flow responses to muscle contraction in the anaesthetized cat1995 · 12 citations
  3. 3The effect of N<sup>G</sup>‐nitro‐<scp>l</scp>‐arginine methyl ester upon basal blood flow and endothelium‐dependent vasodilatation in the dog hindlimb1993 · 39 citations
  4. 4Gender-specific compensation for the lack of NO in the mediation of flow-induced arteriolar dilation2001 · 78 citations
  5. 5The l ‐arginine — nitric oxide pathway in the canine femoral vascular bed: in vitro and in vivo experiments1991 · 11 citations