Why the study?
Does chronic NO synthesis inhibition with L-NAME alter the mechanisms of flow-induced arteriolar dilation differently in male versus female rats?
Population
Male and female rats (control and chronically treated with N-nitro-L-arginine methyl ester [L-NAME] for 4…
Comparison
Chronic L-NAME treatment for 4 weeks, followed… vs Control rats (no L-NAME treatment)
Design
Preclinical
Follow-up
4 weeks
Key result
Chronic L-NAME treatment preserved flow-induced dilation in both genders, mediated by endothelial prostaglandins in males and a cytochrome P-450 metabolite in females.
Authors
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Sex-specific endothelial compensation in rats should not alter practice; leaves open human translation of compensatory pathways.
Does chronic NO synthesis inhibition with L-NAME alter the mechanisms of flow-induced arteriolar dilation differently in male versus female rats?
There are significant gender differences in endothelial adaptation to the lack of nitric oxide synthesis, with males relying on prostaglandins and females on cytochrome P-450 metabolites to maintain flow-induced dilation.
Wu et al. (2001) studied Nitric oxide deficiency. L-NAME vs. Control rats was evaluated on Flow-induced dilation of gracilis muscle arterioles. Chronic L-NAME treatment preserved flow-induced dilation in both genders, mediated by endothelial prostaglandins in males and a cytochrome P-450 metabolite in females.