Why the study?
Does inhibition of nitric oxide formation with L-NMMA alter basal vasomotion and endothelium-dependent responses in the coronary arteries of awake dogs?
Population
4 chronically instrumented awake dogs
Comparison
NG-monomethyl-L-arginine at doses of 5, 15, 50… vs Baseline measurements before L-NMMA infusion
Design
Preclinical
Authors
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Demonstrates NO role in basal coronary tone in awake dogs; leaves open translation to human physiology and practice.
Does inhibition of nitric oxide formation with L-NMMA alter basal vasomotion and endothelium-dependent responses in the coronary arteries of awake dogs?
Nitric oxide plays a significant role in modulating basal vasomotion and stimulated endothelial-dependent dilation in epicardial coronary arteries under physiologic conditions.
Chu et al. (1991) studied this question.
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