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November 1, 1991Journal of Cardiovascular Pharmacology

Endothelium-Derived Nitric Oxide as a Mediator of Acetylcholine-Induced Coronary Vasodilation in Dogs

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Why the study?

Does L-NMMA attenuate acetylcholine-induced coronary vasodilation in open-chest, anesthetized dogs?

Population

Open-chest, anesthetized dogs

Comparison

NG-mono-methyl-L-arginine continuous infusion… vs Baseline (before L-NMMA infusion)

Design

Preclinical

Authors

HIHiroshi IshizakaMaebashi Red Cross HospitalKOKen OkumuraElectrophysiologyHYHiroshige YamabeKoga Hospital

Discussion

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Implication

Does not inform clinical practice; extends in vivo evidence for nitric oxide mediation of coronary vasodilation in canine models.

Structured PICO

Does L-NMMA attenuate acetylcholine-induced coronary vasodilation in open-chest, anesthetized dogs?

P
Population
Open-chest, anesthetized dogs
I
Intervention
NG-mono-methyl-L-arginine (L-NMMA) continuous infusion (2 mumol/min, for 20 min) into the left circumflex coronary artery (LCX)
C
Comparator
Baseline (before L-NMMA infusion)
O
Outcome
Acetylcholine (ACh)-induced increase in left circumflex coronary artery (LCX) blood flowsurrogate

Endothelium-derived nitric oxide is a key mediator of acetylcholine-induced vasodilation in coronary resistance vessels in vivo.

Cite This Study

Ishizaka et al. (1991) studied this question.

synapsesocial.com/papers/6a90d407e55c7a42f270f581https://doi.org/10.1097/00005344-199111000-00003
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regional coronary haemodynamic effects of two inhibitors of nitric oxide synthesis in anaesthetized, open‐chest dogs1991 · 49 citations
  2. 2Effects of inhibition of nitric oxide formation on basal vasomotion and endothelium-dependent responses of the coronary arteries in awake dogs.1991 · 201 citations
  3. 3Effect of an arginine analogue on acetylcholine-induced coronary microvascular dilatation in dogs1991 · 50 citations
  4. 4N‐nitro l ‐arginine causes coronary vasoconstriction and inhibits endothelium‐dependent vasodilatation in anaesthetized greyhounds1991 · 49 citations
  5. 5Nitric oxide modulates epicardial coronary basal vasomotor tone in awake dogs1990 · 85 citations