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June 1, 1991British Journal of PharmacologyOpen Access

N‐nitro l‐arginine causes coronary vasoconstriction and inhibits endothelium‐dependent vasodilatation in anaesthetized greyhounds

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Why the study?

Does N-nitro-L-arginine cause coronary vasoconstriction and inhibit endothelium-dependent vasodilatation in anaesthetized greyhounds?

Population

Anaesthetized greyhounds (n=7)

Comparison

N-nitro-L-arginine 5 mg kg-1 infused into the… vs Baseline responses prior to L-NNA administration

Design

Preclinical

Authors

OWOwen L. WoodmanVascular / Pulmonary VascularGDGregory J. DustingCentre for Eye Research Australia

Discussion

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Implication

Should not inform clinical coronary management; leaves open translation of endothelium-derived NO regulation to human disease.

Structured PICO

Does N-nitro-L-arginine cause coronary vasoconstriction and inhibit endothelium-dependent vasodilatation in anaesthetized greyhounds?

P
Population
Anaesthetized greyhounds (n=7)
I
Intervention
N-nitro-L-arginine (L-NNA) 5 mg kg-1 infused into the left circumflex coronary artery
C
Comparator
Baseline responses prior to L-NNA administration
O
Outcome
Large coronary artery diameter and coronary blood flowsurrogate

Inhibition of nitric oxide biosynthesis with L-NNA causes coronary vasoconstriction and selectively inhibits endothelium-dependent vasodilatation, demonstrating the importance of endothelium-derived NO in regulating coronary vascular tone.

Cite This Study

Woodman et al. (1991) studied this question.

synapsesocial.com/papers/6a88eb9d30fc94fc4b130b29https://doi.org/10.1111/j.1476-5381.1991.tb09802.x
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Also Consider

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  2. 2EFFECTS OF NEUROPEPTIDE Y ON BAROREFLEX CONTROL OF HEART RATE AND MYOCARDIAL CONTRACTILITY IN CONSCIOUS RABBITS1990 · 10 citations
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  4. 4INHIBITION OF ENDOTHELIAL NITRIC OXIDE BIOSYNTHESIS BY N‐NITRO‐l‐ARGININE1990 · 48 citations
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