July 1, 1992British Journal of PharmacologyOpen Access

Effects of nitric oxide synthesis inhibition on the goat coronary circulation under basal conditions and after vasodilator stimulation

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Population

12 instrumented, anaesthetized goats

Comparison

NG-nitro-L-arginine methyl ester 3-4 or 8-10 mg… vs Control conditions

Design

Preclinical

Authors

JGJ L Rueda GarcíaHospital Universitario La Paz NFNúria FernándezUniversidad de Oviedo LMLuis MongeCornell University

Discussion

Member takes

Implication

Suggests basal NO contributes to coronary vasodilator tone in goats; leaves open translation to human coronary physiology.

Structured PICO

Population

12 instrumented, anaesthetized goats

Intervention

NG-nitro-L-arginine methyl ester (L-NAME) 3-4 or 8-10 mg kg-1 injected i.v.

Comparator

Control conditions (basal state before L-NAME administration)

Outcome

Changes in coronary blood flow, systemic arterial blood pressure, heart rate, and coronary vascular resistancesurrogate

Inhibition of endogenous nitric oxide production in goats decreases basal coronary blood flow and increases coronary vascular resistance, suggesting NO provides basal vasodilator tone.

Cite This Study

García et al. (1992) studied this question.

synapsesocial.com/papers/6a8c2f3e95f0361a9ebf08d1 https://doi.org/10.1111/j.1476-5381.1992.tb14375.x

View Full Paper

Ask AI

Bookmark

Effects of nitric oxide synthesis inhibition on the goat coronary circulation under basal conditions and after vasodilator stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of nitric oxide synthesis inhibition on the goat coronary circulation under basal conditions and after vasodilator stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider