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April 1, 1994AJP Heart and Circulatory Physiology

Effects of regional inhibition of nitric oxide synthesis in intact porcine hearts

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Population

Anesthetized pigs (intact porcine hearts)

Comparison

Intracoronary infusion of NO synthesis… vs Baseline/uninhibited state

Design

Preclinical

Authors

KKKnut Arvid KirkebøenOslo University HospitalPNPål Aksel NæssOslo University HospitalJOJon OffstadOslo University Hospital

Discussion

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Implication

Endothelial NO contributes to coronary flow regulation in animals; leaves open translation to human physiology and practice.

Structured PICO

P
Population
Anesthetized pigs (intact porcine hearts)
I
Intervention
Intracoronary infusion of NO synthesis inhibitors: NG-monomethyl-L-arginine (L-NMMA) (30 mumol/min) or NG-nitro-L-arginine (L-NNA) (30 mumol/min)
C
Comparator
Baseline/uninhibited state
O
Outcome
Coronary blood flow (CBF) measured by Doppler flowmetrysurrogate

Nitric oxide produced in the coronary endothelium plays an important role in coronary blood flow regulation in vivo, accounting for approximately 16% of resting flow and contributing to reactive hyperemia after brief ischemia.

Cite This Study

Kirkebøen et al. (1994) studied this question.

synapsesocial.com/papers/6a9747ab209f792fa32700e4https://doi.org/10.1152/ajpheart.1994.266.4.h1516

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nitric oxide regulates coronary blood flow at various coronary arterial pressures in intact porcine hearts1995 · 4 citations
  2. 2Importance of basal nitric oxide synthesis in regulation of myocardial blood flow1991 · 50 citations
  3. 3Regional coronary haemodynamic effects of two inhibitors of nitric oxide synthesis in anaesthetized, open‐chest dogs1991 · 49 citations
  4. 4Endothelium-mediated regulation of coronary tone1991 · 32 citations
  5. 5Role of nitric oxide in reactive hyperemia of the guinea pig heart.1992 · 172 citations