What is the clinical evidence from this study?

Study design: Other. Intervention: NG-nitro-L-arginine (L-NA) vs. L-arginine or baseline. Primary outcome: Myocardial blood flow and vascular resistance.

August 1, 1991Cardiovascular Research

Importance of basal nitric oxide synthesis in regulation of myocardial blood flow

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Key result

NG-nitro-L-arginine significantly reduced coronary blood flow to the left and right ventricle by 30% and 48% respectively after 15 minutes, whereas L-arginine elicited no change.

Population

14 anaesthetised male cats, weight 2.1-3.5 kg

Comparison

Intravenous infusion of NG-nitro-L-arginine or… vs Baseline measurements before infusion

Design

Preclinical

Follow-up

40 minutes

Authors

ZBZoltán BenyóSemmelweis University GKGabriella KissCorvinus University of Budapest CSCsaba SzabóSemmelweis University

Discussion

Member takes

Implication

Endogenous NO regulates basal coronary tone in animals; leaves open relevance to human coronary disease.

Structured PICO

Population

14 anaesthetised male cats weighing 2.1-3.5 kg.

Intervention

Intravenous infusion of NG-nitro-L-arginine (L-NA) (30 mg/kg bolus followed by 1 mg/kg/min infusion) or L-arginine (30 mg/kg bolus followed by 10 mg/kg/min infusion)

Comparator

Baseline measurements before infusion

Outcome

Myocardial blood flow and vascular resistance of the left and right ventricles at 15 and 40 minutessurrogate

Basal coronary vascular tone and resting myocardial blood flow are regulated by endogenous nitric oxide synthesis, which is not limited by exogenous L-arginine availability.

Cite This Study

Benyó et al. (1991) studied this question. NG-nitro-L-arginine (L-NA) vs. L-arginine or baseline was evaluated on Myocardial blood flow and vascular resistance. NG-nitro-L-arginine significantly reduced coronary blood flow to the left and right ventricle by 30% and 48% respectively after 15 minutes, whereas L-arginine elicited no change.

synapsesocial.com/papers/6a9401c4e5eea3f359d68bf0 https://doi.org/10.1093/cvr/25.8.700

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August 1, 1991Cardiovascular Research

Importance of basal nitric oxide synthesis in regulation of myocardial blood flow

View Full Paper

Ask AI

Bookmark

Key result

NG-nitro-L-arginine significantly reduced coronary blood flow to the left and right ventricle by 30% and 48% respectively after 15 minutes, whereas L-arginine elicited no change.

Population

14 anaesthetised male cats, weight 2.1-3.5 kg

Comparison

Intravenous infusion of NG-nitro-L-arginine or… vs Baseline measurements before infusion

Design

Preclinical

Follow-up

40 minutes

Authors

ZBZoltán BenyóSemmelweis University GKGabriella KissCorvinus University of Budapest CSCsaba SzabóSemmelweis University

Discussion

Member takes

Implication

Endogenous NO regulates basal coronary tone in animals; leaves open relevance to human coronary disease.

Structured PICO

Population

14 anaesthetised male cats weighing 2.1-3.5 kg.

Intervention

Intravenous infusion of NG-nitro-L-arginine (L-NA) (30 mg/kg bolus followed by 1 mg/kg/min infusion) or L-arginine (30 mg/kg bolus followed by 10 mg/kg/min infusion)

Comparator

Baseline measurements before infusion

Outcome

Myocardial blood flow and vascular resistance of the left and right ventricles at 15 and 40 minutessurrogate

Basal coronary vascular tone and resting myocardial blood flow are regulated by endogenous nitric oxide synthesis, which is not limited by exogenous L-arginine availability.

Cite This Study

synapsesocial.com/papers/6a9401c4e5eea3f359d68bf0 https://doi.org/10.1093/cvr/25.8.700

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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