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January 2, 1999Fundamental and Clinical Pharmacology

A study on the effects of endogenous nitric oxide on coronary blood flow, myocardial oxygen extraction and cardiac contractility

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Why the study?

Does endogenous nitric oxide inhibition with L-NMMA affect cardiac contractility, myocardial oxygen consumption, and coronary blood flow in anesthetized dogs?

Population

alpha-Chloralose-anesthetized dogs (n = 18)

Comparison

Intracoronary infusion of NG-monomethyl-L-arginin… vs Baseline (control) before L-NMMA infusion

Design

Preclinical

Authors

TOTomoyuki OkuboIbaraki Prefectural University of Health SciencesNSNaoyuki SutoAomori Rosai HospitalSKShigeaki KudoHirosaki University

Discussion

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Implication

Supports NO modulation of canine myocardial function in vivo; extends prior data but leaves open human translation.

Structured PICO

Does endogenous nitric oxide inhibition with L-NMMA affect cardiac contractility, myocardial oxygen consumption, and coronary blood flow in anesthetized dogs?

P
Population
alpha-Chloralose-anesthetized dogs (n = 18)
I
Intervention
Intracoronary infusion of NG-monomethyl-L-arginine (L-NMMA, 2 mg/kg) followed by antagonization with L-arginine (20 mg/kg)
C
Comparator
Baseline (control) before L-NMMA infusion
O
Outcome
Coronary blood flow (CBF), myocardial oxygen extraction (O2-extract), myocardial oxygen consumption (MVO2), and cardiac contractility (Emax)surrogate

Endogenous nitric oxide reduces cardiac contractility and decreases myocardial oxygen consumption while increasing coronary blood flow in vivo.

Cite This Study

Okubo et al. (1999) studied this question.

synapsesocial.com/papers/6a2098668b0daa6b96cd29bfhttps://doi.org/10.1111/j.1472-8206.1999.tb00318.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelium-Derived Nitric Oxide as a Mediator of Acetylcholine-Induced Coronary Vasodilation in Dogs1991 · 24 citations
  2. 2Role of endothelium-derived nitric oxide in myocardial reactive hyperemia1992 · 97 citations
  3. 3Role of adenosine in regulation of coronary flow in dogs with inhibited synthesis of endothelium-derived nitric oxide1996 · 31 citations
  4. 4Controls of ventricular contractility assessed by pressure-volume ratio, Emax1976 · 124 citations
  5. 5Load Independence of the Instantaneous Pressure-Volume Ratio of the Canine Left Ventricle and Effects of Epinephrine and Heart Rate on the Ratio1973 · 1,526 citations