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August 1, 2001AJP Heart and Circulatory Physiology

Endogenous nitric oxide modulates myocardial oxygen consumption in canine right ventricle

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Population

12 open-chest dogs

Comparison

N-nitro-L-arginine methyl ester 150 microg/min… vs Baseline measurements before L-NAME infusion

Design

Preclinical

Authors

SSSrinath SettyUniversity of North TexasXBXiaoming BianDalian Medical UniversityJTJohnathan D. TuneUniversity of North Texas

Discussion

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Implication

Endogenous NO may constrain RV oxygen use at high flows in swine; hypothesis-generating for RV energetics in human disease.

Structured PICO

P
Population
12 open-chest dogs
I
Intervention
N(omega)-nitro-L-arginine methyl ester (L-NAME) 150 microg/min infused into the right coronary artery during adenosine-induced maximal coronary vasodilation
C
Comparator
Baseline measurements before L-NAME infusion
O
Outcome
Right ventricular myocardial oxygen consumption (MVO2) at normal and elevated right coronary perfusion pressuressurrogate

Endogenous nitric oxide limits right ventricular myocardial oxygen consumption, with greater effects at higher coronary flows.

Cite This Study

Setty et al. (2001) studied this question.

synapsesocial.com/papers/6a70975635aa2c282ce1e9b7https://doi.org/10.1152/ajpheart.2001.281.2.h831
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Importance of basal nitric oxide synthesis in regulation of myocardial blood flow1991 · 50 citations
  2. 2Nitric oxide is an important determinant of coronary flow at rest and during hypoxemic stress in fetal lambs1995 · 47 citations
  3. 3Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs.1993 · 303 citations
  4. 4Persistent right coronary flow reserve at low perfusion pressure1989 · 20 citations
  5. 5Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.1987 · 5,095 citations