Why the study?
Does nitric oxide synthesis inhibition alter the coronary blood flow response to increased metabolic demand in dogs with pacing-induced heart failure?
Population
Anesthetized dogs with heart failure produced by rapid ventricular pacing, and control dogs
Comparison
Intracoronary infusion of Nomega-nitro-L-arginine… vs Control dogs without heart failure; baseline…
Design
Preclinical
Authors
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NO mediates coronary flow response to tachycardia in HF dogs; extends mechanistic insights but leaves open human translation.
Does nitric oxide synthesis inhibition alter the coronary blood flow response to increased metabolic demand in dogs with pacing-induced heart failure?
In a canine model of heart failure, endothelium-derived nitric oxide plays a significant role in regulating coronary blood flow during increased metabolic demand.
Tada et al. (2001) studied this question.
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