Population
Open-chest dogs (n=20) and isolated canine coronary arterioles (n=8)
Comparison
Adenosine and left atrial pacing after… vs Responses to adenosine and pacing before L-NAME…
Design
Preclinical
Authors
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NO inhibition attenuates coronary arteriolar dilation to adenosine in animals; hypothesis-generating for NO's role in human coronary reserve.
Inhibition of nitric oxide synthesis attenuates coronary dilation during adenosine infusions and pacing-induced metabolic demand, suggesting NO preserves the tone and vasodilator reserve of arterioles.
Jones et al. (1995) studied this question.
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