Key result
Intracoronary infusion of L-NAME did not alter pacing-induced increases in coronary blood flow, myocardial oxygen consumption, or regional myocardial blood flow in anesthetized dogs.
Why the study?
Does inhibition of EDNO synthesis with L-NAME alter metabolic coronary vasodilation induced by pacing tachycardia in anesthetized dogs?
Population
Anesthetized dogs
Comparison
Intracoronary infusion of N… vs Baseline state before L-NAME infusion
Design
Preclinical
Authors
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EDNO inhibition does not affect metabolic coronary vasodilation in dogs; leaves open its role in other species or human physiology.
Does inhibition of EDNO synthesis with L-NAME alter metabolic coronary vasodilation induced by pacing tachycardia in anesthetized dogs?
Endothelium-derived nitric oxide does not play a primary role in mediating metabolic coronary vasodilation induced by pacing tachycardia in dogs.
Katsuda et al. (1995) studied this question. L-NAME (N omega-nitro-L-arginine-methyl-ester) vs. Before L-NAME infusion was evaluated on Changes in coronary blood flow (CBF), regional myocardial blood flow (MBF), and myocardial oxygen consumption (MVO2). Intracoronary infusion of L-NAME did not alter pacing-induced increases in coronary blood flow, myocardial oxygen consumption, or regional myocardial blood flow in anesthetized dogs.
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