Why the study?
Does intracoronary L-NMMA alter coronary vasodilatation induced by rapid pacing in patients without significant coronary artery disease?
Population
19 patients without significant coronary artery disease
Comparison
Intracoronary infusion of NG-monomethyl-L-arginin… vs Rapid atrial pacing before L-NMMA infusion
Design
Other
Authors
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Supports vessel-specific NO dependence without microvascular effects; hypothesis-generating and should not change practice.
Does intracoronary L-NMMA alter coronary vasodilatation induced by rapid pacing in patients without significant coronary artery disease?
Nitric oxide mediates pacing-induced metabolic vasodilatation in large epicardial coronary arteries but not in resistance vessels in humans.
Egashira et al. (1996) studied this question.
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