Key result
NG-nitro-L-arginine increased total peripheral resistance and arterial pressure in healthy dogs, but did not change any haemodynamic variable in dogs with pacing-induced heart failure.
Why the study?
Does NG-nitro-L-arginine alter haemodynamic variables differently in dogs with pacing-induced heart failure compared to healthy dogs?
Population
5 conscious dogs with and without pacing-induced heart failure
Comparison
NG-nitro-L-arginine, an inhibitor of nitric… vs Healthy state (dogs without heart failure)
Design
Preclinical
Authors
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Hypothesis-generating for endothelial dysfunction in experimental HF; leaves open relevance to human disease.
Does NG-nitro-L-arginine alter haemodynamic variables differently in dogs with pacing-induced heart failure compared to healthy dogs?
Inhibition of nitric oxide synthesis fails to induce systemic vasoconstriction in dogs with heart failure, suggesting impaired endothelium-dependent vasomotor control in this condition.
Eisner et al. (1991) studied Heart failure (n=5). NG-nitro-L-arginine (NNA) vs. Healthy dogs was evaluated on Haemodynamic effects (total peripheral resistance, arterial pressure, cardiac output, heart rate). NG-nitro-L-arginine increased total peripheral resistance and arterial pressure in healthy dogs, but did not change any haemodynamic variable in dogs with pacing-induced heart failure.
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