Nitric Oxide Inhibition in an Ovine Model of Heart Failure
Population
6 sheep before (normal) and after induction of heart failure (HF) by rapid left ventricular pacing
Comparison
N-monomethyl-L-arginine given as incremental… vs Normal state and concurrent L-arginine…
Design
Preclinical
Follow-up
30-60 minutes
Authors
Discussion
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Member takes
Implication
Indicates blunted NO dependence in experimental HF; leaves open relevance to human disease.
Structured PICO
P
Population
6 sheep before (normal) and after induction of heart failure (HF) by rapid left ventricular pacing
I
Intervention
N(G)-monomethyl-L-arginine (L-NMMA) given as incremental bolus doses
C
Comparator
Normal state (before HF induction) and concurrent L-arginine administration
O
Outcome
Acute haemodynamic, hormonal and renal effects (including left ventricular systolic pressure, mean arterial pressure, peripheral resistance, left atrial pressure, and cardiac output)surrogate
Endogenous nitric oxide plays an important haemodynamic role in the normal state, but there is a blunted pressor response to NO inhibition in pacing-induced heart failure.
Cite This Study
Rademaker et al. (1996) studied this question.