Key result
Infusion of L-NMMA significantly increased mean arterial blood pressure and vascular resistance, and reduced cardiac output compared to placebo.
Why the study?
Does nitric oxide inhibition with L-NMMA alter systemic and pulmonary haemodynamics in normal male volunteers?
Population
10 normal male volunteers, mean age 26 +/- 1.6 years
Comparison
Continuous infusion of N-monomethyl-L-arginine… vs Volume matched placebo
Design
RCT, randomised, double-blind, placebo controlled
Follow-up
12 min
Authors
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L-NMMA alters hemodynamics in healthy volunteers; confirms basal nitric oxide maintains vascular tone.
RCT (n=10)
Double-blind
Crossover
Does nitric oxide inhibition with L-NMMA alter systemic and pulmonary haemodynamics in normal male volunteers?
Nitric oxide inhibition with L-NMMA significantly increases vascular resistance and reduces cardiac output, demonstrating the critical role of basal nitric oxide in maintaining vascular tone in humans.
Kiely et al. (1998) conducted an RCT in Healthy volunteers (n=10). N(G)-monomethyl-L-arginine (L-NMMA) vs. Placebo was evaluated on Systemic and pulmonary haemodynamics (MAP, SVR, TPR, HR, SV, CO). Infusion of L-NMMA significantly increased mean arterial blood pressure and vascular resistance, and reduced cardiac output compared to placebo.
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