Key result
L-NMMA infusion cuts nasal NO by ~64% while raising mean arterial pressure and shortening bleeding time.
Why the study?
The effects of more prolonged and higher dose inhibition of endogenous nitric oxide production on hemodynamics, sympathetic activity, and bleeding time in humans were not well characterized.
Does NG-monomethyl-L-arginine (L-NMMA) infusion alter hemodynamics, sympathetic activity, and bleeding time in healthy volunteers?
Comparison
L-NMMA infusion at 0.3 mg.kg-1.min-1 for 30 min followed by 0.15 or 0.3 mg.kg-1.min-1 for 30 min
Design
Physiological study with invasive hemodynamic measurements
Follow-up
90 minutes post-infusion
Authors
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L-NMMA infusion safely raises BP and shortens bleeding time in volunteers; leaves open therapeutic translation to vasodilatory shock.
Does NG-monomethyl-L-arginine (L-NMMA) infusion alter hemodynamics, sympathetic activity, and bleeding time in healthy volunteers?
p-value: p=<0.01
Prolonged inhibition of endogenous nitric oxide production with L-NMMA in healthy volunteers causes moderate hypertension, transient cardiac output reduction, sympathetic withdrawal, and shortened bleeding time.
Albert et al. (1997) studied Healthy (n=8). NG-monomethyl-L-arginine (L-NMMA) was evaluated on Hemodynamics, endogenous NO levels in nasal air, bleeding time, and plasma cGMP and catecholamines (p=<0.01). Infusion of L-NMMA in healthy volunteers reduced nasal NO concentrations by 64% and shortened bleeding time by 31% (P<0.01), while elevating mean arterial pressure by 12%.
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