Why the study?
Does intravenous infusion of N(G)-monomethyl-L-arginine alter muscle sympathetic nerve activity and blood flow in healthy humans compared to phenylephrine?
Population
15 healthy humans (n=8 in low dose group, n=7 in high dose group)
Comparison
Intravenous infusion of N-monomethyl-L-arginine… vs Equipressor dose of phenylephrine
Design
Other
Follow-up
15 minutes
Authors
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Dose-specific sympathetic effects of NOS inhibition merit attention in study design; leaves open relevance to hypertension or heart failure.
Does intravenous infusion of N(G)-monomethyl-L-arginine alter muscle sympathetic nerve activity and blood flow in healthy humans compared to phenylephrine?
Inhibition of nitric oxide synthase by N(G)-monomethyl-L-arginine has dose-dependent sympathetic effects in humans, exerting sympatho-excitatory effects at lower doses and sympathoinhibitory effects at higher doses.
Lepori et al. (1998) studied this question.
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