Why the study?
Does systemic inhibition of NO synthase by L-NMMA infusion alter sympathetic nerve activity and vascular tone at rest and during static exercise in humans?
Population
Humans
Comparison
Systemic inhibition of NO synthase by… vs Phenylephrine infusion
Design
Other
Authors
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L-NMMA raises BP without sympathetic activation in humans; leaves open central NO modulation of outflow during exercise or disease.
Does systemic inhibition of NO synthase by L-NMMA infusion alter sympathetic nerve activity and vascular tone at rest and during static exercise in humans?
Nitric oxide is involved in the central regulation of sympathetic outflow in humans, suggesting both neuronal and endothelial NO synthesis contribute to vasomotor tone regulation.
Owlya et al. (1997) studied this question.
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