Why the study?
Does nitric oxide synthase inhibition with L-NMMA alter central sympathetic outflow in healthy humans?
Population
Healthy human subjects
Comparison
Intravenous infusion of the nitric oxide… vs Phenylephrine and experimental attenuation of…
Design
Other
Authors
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L-NMMA raises pressure while suppressing sympathetic activity in healthy humans; challenges animal models but leaves open disease relevance.
Does nitric oxide synthase inhibition with L-NMMA alter central sympathetic outflow in healthy humans?
In healthy humans, nitric oxide does not appear to be involved in the tonic restraint of central sympathetic outflow, challenging findings from experimental animal models.
Hansen et al. (1994) studied this question.
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