Why the study?
Does L-NMMA alter renal hemodynamics and sodium excretion in healthy humans?
Population
23 healthy subjects
Comparison
Bolus injection of L-NMMA vs Placebo (10 ml saline)
Design
RCT, randomized, placebo-controlled
Follow-up
120 minutes
Authors
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Acute NO inhibition alters renal function in healthy humans; confirms nitric oxide as a tonic regulator of renal hemodynamics and sodium excretion.
Does L-NMMA alter renal hemodynamics and sodium excretion in healthy humans?
Inhibition of NO synthesis with L-NMMA in healthy humans reduces renal plasma flow, glomerular filtration rate, and sodium excretion, confirming NO's role as a tonic vasodilator and regulator of sodium excretion.
Bech et al. (1996) studied this question.