Why the study?
Does intravenous L-NMMA alter renal function and systemic hemodynamics in healthy men?
Population
8 healthy men
Comparison
N-monomethyl-L-arginine intravenously vs Saline placebo intravenously
Design
Other
Authors
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Basal NO regulates vascular tone and renal sodium handling in humans; leaves open whether NO modulation offers therapeutic targets.
Does intravenous L-NMMA alter renal function and systemic hemodynamics in healthy men?
Basal nitric oxide generation plays an important physiological role in inhibiting tubular sodium reabsorption and regulating systemic vascular tone in humans.
Haynes et al. (1997) studied this question.
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