Why the study?
Does NG-monomethyl-L-arginine (L-NMMA) affect mean arterial pressure and fractional excretion of sodium in healthy humans?
Does NG-monomethyl-L-arginine (L-NMMA) affect mean arterial pressure and fractional excretion of sodium in healthy humans?
Nitric oxide inhibition with L-NMMA increases blood pressure dose-dependently and reduces renal sodium excretion in healthy humans, demonstrating that sodium excretion is highly sensitive to small changes in NO bioavailability.
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NO inhibition modulates BP and sodium excretion in health; leaves open translation to hypertension or HF management.
Larsen et al. (2012) studied this question.
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