Why the study?
Does acute nitric oxide inhibition with L-NMMA alter systemic and glomerular hemodynamics in adult male Munich-Wistar rats?
Population
Adult male Munich-Wistar rats
Comparison
Intravenous administration of… vs Intravenous pure saline
Design
Preclinical
Follow-up
acute
Authors
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No immediate clinical implications; leaves open nitric oxide's role in human glomerular disease.
Does acute nitric oxide inhibition with L-NMMA alter systemic and glomerular hemodynamics in adult male Munich-Wistar rats?
Acute inhibition of nitric oxide synthesis in rats demonstrates that endothelium-derived relaxing factor (NO) exerts a basal relaxing effect on the glomerular microcirculation.
Zatz et al. (1991) studied this question.
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