Why the study?
Does arterial waveform analysis detect nitric oxide-mediated changes in arterial smooth muscle tone in healthy volunteers?
Population
15 healthy male volunteers
Comparison
Intravenous infusion of L-NAME followed by… vs Pre-treatment baseline values and D-arginine vs…
Design
Other, blinded fashion (for L-arginine vs D-arginine administration)
Authors
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Arterial waveform analysis detects nitric oxide effects on vascular tone in volunteers; leaves open clinical translation and requires prospective validation.
Does arterial waveform analysis detect nitric oxide-mediated changes in arterial smooth muscle tone in healthy volunteers?
Pressure pulse contour analysis is a sensitive technique for tracking changes in arterial pulsatile function accompanying nitric oxide-mediated alterations in vascular tone.
McVeigh et al. (2001) studied this question.
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