Key result
Infusion of L-NMMA decreased epicardial coronary diameter by 5.5% (from 3.47 to 3.28 mm) in awake dogs, supporting nitric oxide's role in modulating basal vasomotor tone.
Why the study?
Does L-NMMA infusion alter resting epicardial coronary diameter and coronary flow in awake dogs?
Population
7 awake dogs chronically instrumented with coronary dimension crystals and Doppler flow probes
Comparison
NG-monomethyl-L-arginine (L-NMMA) 5 mg/kg infusion vs Baseline measurements prior to infusion, and…
Design
Preclinical
Follow-up
Acute observation (>90 min)
Authors
Loading...
Supports nitric oxide modulation of basal coronary tone in awake animals; leaves open translation to human vasomotor function.
Does L-NMMA infusion alter resting epicardial coronary diameter and coronary flow in awake dogs?
Effect estimate: 5.5% decrease
Absolute Event Rate: 3.28% vs 3.47%
Endogenous nitric oxide plays an important role in modulating basal epicardial coronary vasomotor tone and systemic vascular resistance in awake dogs.
Chu et al. (1990) studied Basal coronary vasomotor tone (n=7). NG-monomethyl-L-arginine (L-NMMA) vs. Baseline was evaluated on Epicardial coronary diameter (5.5% decrease). Infusion of L-NMMA decreased epicardial coronary diameter by 5.5% (from 3.47 to 3.28 mm) in awake dogs, supporting nitric oxide's role in modulating basal vasomotor tone.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: