Key result
In conscious dogs, L-NAME increased the critical coronary pressure at which myocardial ischemia began from 45 +/- 3 mm Hg to 61 +/- 2 mm Hg (P < .001).
Why the study?
Does nitric oxide synthesis inhibition with L-NAME alter coronary autoregulatory responses in conscious dogs?
Population
Conscious (unanesthetized) dogs
Comparison
N omega-nitro-L-arginine methyl ester 10 mg/kg vs Control conditions
Design
Preclinical
Authors
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NO inhibition raises ischemic threshold in conscious dogs; hypothesis-generating for coronary autoregulation in humans.
Does nitric oxide synthesis inhibition with L-NAME alter coronary autoregulatory responses in conscious dogs?
Absolute Event Rate: 61% vs 45%
p-value: p=<.001
Inhibition of nitric oxide synthesis impairs coronary autoregulation during ischemia in conscious dogs, suggesting NO is crucial for flow-dependent resistance adjustments.
Smith et al. (1993) studied Coronary autoregulation. N omega-nitro-L-arginine methyl ester (L-NAME) vs. Control conditions was evaluated on Critical pressure at which myocardial ischemia began (lower autoregulatory break point) (p=<.001). In conscious dogs, L-NAME increased the critical coronary pressure at which myocardial ischemia began from 45 +/- 3 mm Hg to 61 +/- 2 mm Hg (P < .001).
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