What question did this study set out to answer?

To determine whether nitric oxide synthesized from L-arginine mediates vasomotor tone and vasodilation in resistance coronary vessels of conscious animals.

January 1, 1992AJP Heart and Circulatory Physiology

Contribution of nitric oxide to dilation of resistance coronary vessels in conscious dogs

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Authors

RPR ParentInstitut National de Santé Publique du Québec RPRené ParéProgamme National Contre le Tuberculose MLMichel LavalléeBoehringer Ingelheim (Germany)

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Implication

In vivo animal study reveals that nitric oxide regulates resistance coronary dilation in conscious dogs, indicating its vital role in reactive hyperemia and pharmacological blood flow regulation.

Key Points

To determine whether nitric oxide synthesized from L-arginine mediates vasomotor tone and vasodilation in resistance coronary vessels of conscious animals.
Measured coronary blood flow (CBF) in conscious dogs following intracoronary injections of acetylcholine (3.0 ng/kg), adenosine (100 ng/kg), nitroglycerin (175 ng/kg), and a 15-second coronary arterial occlusion.
Assessed CBF responses before and after nitric oxide synthase inhibition with intracoronary N omega-nitro-L-arginine (10 µg/kg/min for 12 min), followed by administration of L-arginine (1.0 mg/kg/min for 12 min) to evaluate reversal.
Inhibition of nitric oxide formation reduced acetylcholine-induced CBF increases from 7.2 ± 1.1 ml to 2.4 ± 0.5 ml and adenosine-induced CBF increases from 12.4 ± 1.4 ml to 6.4 ± 0.7 ml (both P < 0.01), while nitroglycerin responses remained unchanged (7.4 ± 1.2 ml before vs. 7.2 ± 1.1 ml after).
The CBF repayment-to-debt ratio during reactive hyperemia following transient ischemia decreased significantly from 2.8 ± 0.2 to 1.7 ± 0.1 (P < 0.01), and subsequent infusion of L-arginine partially reversed the inhibition of acetylcholine-induced CBF increases.

Cite This Study

Parent et al. (1992) studied this question.

synapsesocial.com/papers/6a1aa12e5448f1e38b45e1fb https://doi.org/10.1152/ajpheart.1992.262.1.h10

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Implication

In vivo animal study reveals that nitric oxide regulates resistance coronary dilation in conscious dogs, indicating its vital role in reactive hyperemia and pharmacological blood flow regulation.

Contribution of nitric oxide to dilation of resistance coronary vessels in conscious dogs

Discussion

Member takes

Implication

Key Points

Cite This Study

Contribution of nitric oxide to dilation of resistance coronary vessels in conscious dogs

Discussion

Member takes

Implication

Key Points

Cite This Study

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