Key result
Infusion of the NO synthase inhibitor LNMMA increased aortic augmentation index by 25% (95% CI 12-38) and mean arterial pressure by 16 mmHg (95% CI 9-23) compared with placebo in healthy men.
Why the study?
Does inhibition of basal nitric oxide synthesis with LNMMA increase large artery stiffness in healthy men?
RCT (n=8)
Does inhibition of basal nitric oxide synthesis with LNMMA increase large artery stiffness in healthy men?
Effect estimate: 25% increase (95% CI 12-38)
Inhibition of basal nitric oxide synthesis with LNMMA acutely increases large artery stiffness and mean arterial pressure in healthy men, demonstrating NO's role in regulating arterial stiffness in vivo.
No takes yet. Share an insight, caveat, or question.
NO synthase inhibition increases arterial stiffness; confirms basal nitric oxide as a key regulator and supports targeted studies in endothelial dysfunction.
Wilkinson et al. (2002) conducted an RCT in Healthy (n=8). L-N(G)-monomethyl arginine (LNMMA) vs. Placebo (saline) was evaluated on Aortic augmentation index (AIx) (25% increase, 95% CI 12-38). Infusion of the NO synthase inhibitor LNMMA increased aortic augmentation index by 25% (95% CI 12-38) and mean arterial pressure by 16 mmHg (95% CI 9-23) compared with placebo in healthy men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: