Why the study?
Does local nitric oxide production regulate large-artery distensibility in an ovine model?
Population
Anesthetized sheep (ovine hind-limb preparation)
Comparison
Intra-arterial infusion of… vs Baseline or co-infusion
Design
Preclinical
Authors
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Does not alter clinical management of arterial stiffness; leaves open whether NO modulation reduces PWV in humans.
Does local nitric oxide production regulate large-artery distensibility in an ovine model?
Basal nitric oxide production influences large-artery distensibility in vivo, suggesting that reversing endothelial dysfunction may reduce arterial stiffness.
Wilkinson et al. (2002) studied this question.
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