Why the study?
Does L-NAME or L-arginine alter hemodynamics and vascular changes in rats with heart failure following myocardial infarction?
Population
Rats with coronary artery ligation (heart failure, HF) or sham operation (SO)
Comparison
NG-nitro-L-arginine methyl ester (L-NAME, 6… vs Untreated rats with HF or SO
Design
Preclinical
Follow-up
four weeks
Key result
Treatment with L-NAME reversed the effects of heart failure on left ventricular systolic pressure (143 vs 111 mmHg, p<0.05), mean blood pressure, and aortic media thickness in rats.
Authors
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L-NAME reverses hemodynamic and vascular changes in rat post-MI HF; hypothesis-generating for endothelial NO modulation in human HF.
Does L-NAME or L-arginine alter hemodynamics and vascular changes in rats with heart failure following myocardial infarction?
p-value: p=<0.05
Endothelial NO plays an important role in mediating reduced vascular growth, myocardial dysfunction, and hypotension in rats with heart failure.
Cunha et al. (2004) studied Heart failure following myocardial infarction in rats. L-NAME or L-arginine vs. Untreated heart failure or sham operation was evaluated on Left ventricular systolic pressure (LVSP), mean blood pressure (MBP), aortic media thickness, and reactivity (p=<0.05). Treatment with L-NAME reversed the effects of heart failure on left ventricular systolic pressure (143 vs 111 mmHg, p<0.05), mean blood pressure, and aortic media thickness in rats.
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