Key result
In rats with chronic heart failure, NO synthase inhibition with L-NNA did not alter afferent arteriolar baseline diameter or ANG II responsiveness, unlike in sham-operated rats.
Population
Rats with experimental heart failure induced by coronary artery ligation 8-10 weeks prior
Comparison
NO synthase inhibition and ANG II in the… vs Kidneys from sham-operated rats
Design
Preclinical
Follow-up
8-10 weeks
Authors
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Animal data link HF to impaired NO modulation of renal ANG II responses; leaves open clinical translation.
p-value: p=<0.05
Experimental heart failure in rats leads to a loss of NO-dependent modulation of ANG II-induced renal vasoconstriction due to diminished NO synthesis and augmented degradation.
Ikenaga et al. (1999) studied chronic heart failure. NO synthase inhibition (L-NNA) vs. Sham-operated rats was evaluated on Afferent arteriolar diameter and ANG II responsiveness (p=<0.05). In rats with chronic heart failure, NO synthase inhibition with L-NNA did not alter afferent arteriolar baseline diameter or ANG II responsiveness, unlike in sham-operated rats.
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