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April 16, 2008Acta Physiologica

Reduction in blood pressure and regression of LVH were observed in all recovery groups, but reduction in LV fibrosis and aortic thickening were not; NO-synthase activity was restored only in the L-arginine and spironolactone groups.

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Why the study?

Does L-arginine or spironolactone reverse left ventricular hypertrophy and aortic remodelling in L-NAME-induced hypertensive rats?

Population

Male adult Wistar rats with N(omega)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension

Comparison

L-arginine or spironolactone for 3 weeks vs Spontaneous reversion and healthy controls

Design

Preclinical

Follow-up

7 weeks (4 weeks induction + 3 weeks recovery)

Authors

LPLudovít PaulisComenius University BratislavaJMJana MatuskováComenius University BratislavaMAMichaela AdamcováUniversity Hospital Hradec Králové

Discussion

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Overview

Should not yet inform human hypertension therapy; extends evidence on selective regression of LVH versus fibrosis in this model.

Structured PICO

Does L-arginine or spironolactone reverse left ventricular hypertrophy and aortic remodelling in L-NAME-induced hypertensive rats?

P
Population
Male adult Wistar rats with N(omega)-nitro-L-arginine methyl ester (L-NAME)-induced hypertension
I
Intervention
L-arginine or spironolactone for 3 weeks (following 4 weeks of L-NAME administration)
C
Comparator
Spontaneous reversion (placebo for 3 weeks following 4 weeks of L-NAME) and healthy controls
O
Outcome
Reversion of left ventricular hypertrophy, LV fibrosis, and aortic remodellingsurrogate

In L-NAME-induced hypertensive rats, regression of LVH and hypertension occurs independently of NO-synthase restoration, while LV fibrosis and aortic remodeling are more resistant to regression.

Cite This Study

Paulis et al. (2008) studied this question.

synapsesocial.com/papers/6a8d129dd8903deb3bd4fbb3https://doi.org/10.1111/j.1748-1716.2008.01862.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spontaneous, L-Arginine-Induced and Spironolactone-Induced Regression of Protein Remodeling of the Left Ventricle in L-NAME-Induced Hypertension2007 · 4 citations
  2. 2Spironolactone differently influences remodeling of the left ventricle and aorta in L-NAME-induced hypertension2007 · 15 citations
  3. 3Role of nitric oxide in mediating cardiovascular alterations accompanying heart failure in rats2004 · 10 citations
  4. 4Regression of L-NAME–Induced Hypertension: The Role of Nitric Oxide and Endothelium-Derived Constricting Factor2008 · 86 citations
  5. 5Mechanism of Structural Remodelling of the Rat Aorta During Long-Term NG-Nitro-L-arginine Methyl Ester Treatment1999 · 15 citations