April 1, 2008Hypertension ResearchOpen Access

Regression of L-NAME–Induced Hypertension: The Role of Nitric Oxide and Endothelium-Derived Constricting Factor

Q: What is the clinical evidence from this study?

Study design: Other. Population: L-NAME-induced hypertension (n=32). Intervention: L-NAME withdrawal (spontaneous recovery) vs. Continuous L-NAME or age-matched controls. Primary outcome: Systolic blood pressure (p=<0.01).

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Key result

Cessation of L-NAME administration in hypertensive rats functionally restored NO signaling but only partially reduced systolic blood pressure, which remained 10% higher than controls.

Population

Male adult Wistar rats

Comparison

Spontaneous recovery vs Continuous L-NAME administration and age-matched…

Design

Preclinical

Follow-up

3 weeks

Authors

LPLudovít Paulis JZJosef Zicha JKJaroslav Kuneš

Discussion

Member takes

Overview

Highlights persistent vascular remodeling limiting full BP normalization after NO recovery in rats; hypothesis-generating for mechanisms in human hypertension.

Structured PICO

Population

32 male 10-week-old Wistar rats were studied to evaluate the spontaneous regression of L-NAME-induced hypertension over 3 weeks.

Intervention

Spontaneous recovery (discontinuation of L-NAME administration for 3 weeks after 5 weeks of L-NAME treatment)

Comparator

Continuous L-NAME administration (5 weeks) and age-matched untreated controls (5- and 8-week)

Outcome

NO-mediated and EDCF-mediated components of acetylcholine-induced responses in preconstricted small mesenteric and femoral arteriessurrogate

Main Result

p-value: p=<0.01

In a rat model of L-NAME-induced hypertension, cessation of the drug restores NO signaling but does not fully reverse structural arterial alterations, enhanced EDCF formation, or elevated blood pressure.

Limitations

Relatively low number of animals employed does not allow definitive conclusions regarding the source of variance in SBP.

Cite This Study

Paulis et al. (2008) studied L-NAME-induced hypertension (n=32). L-NAME withdrawal (spontaneous recovery) vs. Continuous L-NAME or age-matched controls was evaluated on Systolic blood pressure (p=<0.01). Cessation of L-NAME administration in hypertensive rats functionally restored NO signaling but only partially reduced systolic blood pressure, which remained 10% higher than controls.

synapsesocial.com/papers/6a23fe959e1c90a91c098737 https://doi.org/10.1291/hypres.31.793

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April 1, 2008Hypertension ResearchOpen Access

Regression of L-NAME–Induced Hypertension: The Role of Nitric Oxide and Endothelium-Derived Constricting Factor

View Full Paper

Ask AI

Bookmark

Key result

Cessation of L-NAME administration in hypertensive rats functionally restored NO signaling but only partially reduced systolic blood pressure, which remained 10% higher than controls.

Population

Male adult Wistar rats

Comparison

Spontaneous recovery vs Continuous L-NAME administration and age-matched…

Design

Preclinical

Follow-up

3 weeks

Authors

LPLudovít Paulis JZJosef Zicha JKJaroslav Kuneš

Discussion

Member takes

Overview

Highlights persistent vascular remodeling limiting full BP normalization after NO recovery in rats; hypothesis-generating for mechanisms in human hypertension.

Structured PICO

Population

32 male 10-week-old Wistar rats were studied to evaluate the spontaneous regression of L-NAME-induced hypertension over 3 weeks.

Intervention

Spontaneous recovery (discontinuation of L-NAME administration for 3 weeks after 5 weeks of L-NAME treatment)

Comparator

Continuous L-NAME administration (5 weeks) and age-matched untreated controls (5- and 8-week)

Outcome

NO-mediated and EDCF-mediated components of acetylcholine-induced responses in preconstricted small mesenteric and femoral arteriessurrogate

Main Result

p-value: p=<0.01

Limitations

Relatively low number of animals employed does not allow definitive conclusions regarding the source of variance in SBP.

Cite This Study

synapsesocial.com/papers/6a23fe959e1c90a91c098737 https://doi.org/10.1291/hypres.31.793

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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