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October 1, 1993Journal of Hypertension

Persistent hypertension following inhibition of nitric oxide formation in the young Wistar rat: role of renin and vascular hypertrophy

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Population

Three-week-old normotensive Wistar rats

Design

Preclinical

Follow-up

14 weeks after stopping treatment

Authors

JMJames J. MortonEBElisabeth BeattieASAngela Speirs

Discussion

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Overview

Supports renin-dependent model of persistent hypertension after nitric oxide inhibition; hypothesis-generating for human translation.

Structured PICO

P
Population
Three-week-old normotensive Wistar rats
I
Intervention
NG-nitro-L-arginine methyl ester (L-NAME) 100 or 40 mg/kg per day, or 40 mg/kg per day L-NAME plus 100 mg/kg per day captopril in drinking water for 4 to 7 weeks
O
Outcome
Systolic blood pressure during treatment and after treatment cessationsurrogate

Chronic inhibition of nitric oxide production with L-NAME in young rats induces a persistent, renin-dependent form of hypertension.

Cite This Study

Morton et al. (1993) studied this question.

synapsesocial.com/papers/6a7bf56ba2188deaa4c2869chttps://doi.org/10.1097/00004872-199310000-00012
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hormonal, renal, and metabolic alterations during hypertension induced by chronic inhibition of NO in rats1994 · 72 citations
  2. 2Evolution of Chronic Nitric Oxide Inhibition Hypertension1998 · 74 citations
  3. 3Sodium Sensitivity And Sympathetic Nervous System In Hypertension Induced By Long‐Term Nitric Oxide Blockade In Rats2000 · 15 citations
  4. 4Hypertension and Impairment of Endothelium-Dependent Relaxation of Arteries from Spontaneously Hypertensive and L-NAME-Treated Wistar Rats.2001 · 22 citations
  5. 5Cardiac weight in hypertension induced by nitric oxide synthase blockade.1993 · 183 citations