Key result
Renal denervation significantly delayed and attenuated the development of L-NAME-induced hypertension in rats, which rose to 154 mm Hg in sham-operated rats vs 115 mm Hg in controls (P<.005).
Why the study?
Does renal denervation attenuate L-NAME-induced hypertension in Sprague-Dawley rats?
Population
32 Sprague-Dawley rats (4 groups of n=8 each)
Comparison
Renal denervation followed by L-NAME for 4 weeks vs Sham-operated vehicle-treated, sham-operated…
Design
Preclinical
Follow-up
4 weeks
Authors
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Animal data extend renal nerve role in experimental hypertension; leaves open human translation of renal denervation.
Does renal denervation attenuate L-NAME-induced hypertension in Sprague-Dawley rats?
Absolute Event Rate: 154% vs 115%
p-value: p=<.005
Renal denervation attenuates L-NAME-induced hypertension in rats, suggesting that this form of hypertension is partly dependent on the integrity of the renal nerves.
Matsuoka et al. (1994) studied Hypertension (n=32). Renal denervation + L-NAME vs. Sham surgery + L-NAME, and vehicle controls was evaluated on Arterial pressure at 4 weeks (p=<.005). Renal denervation significantly delayed and attenuated the development of L-NAME-induced hypertension in rats, which rose to 154 mm Hg in sham-operated rats vs 115 mm Hg in controls (P<.005).
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